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Full Paper Co-administration of Antimicrobial Peptides (AMPs) EnhancesToll-like Receptor 4 (TLR4) Antagonist Activity of a Synthetic Glycolipid Authors Francesco Peri, Fabio Alessandro Facchini, Helena Coelho, Stefania Enza Sestito, Sandra Delgado, Alberto Minotti, David Andreu, Jesús Jiménez-Barbero ChemMedChem Abstract This study describes the effect of co-administration of antimicrobial peptides (AMPs) and synthetic glycolipid FP7, active in inhibiting inflammatory cytokine production caused by TLR4 activation and signaling. The co-administration of two
Int. J. Mol. Sci. 2017, 18(11), 2318; doi:10.3390/ijms18112318 Abstract The interactions between sugar-containing molecules from the bacteria cell wall and pattern recognition receptors (PRR) on the plasma membrane or cytosol of specialized host cells are the first molecular events required for the activation of higher animal’s immune response and inflammation. This review focuses on the role of carbohydrates of bacterial endotoxin (lipopolysaccharide, LPS, lipooligosaccharide, LOS, and lipid A), in the interaction